The Substance (2024) Cast & Character Guide — No Spoilers | Who's That?

Who plays who in The Substance (2024)? Browse a spoiler-free character guide with photos of every major character and the actors behind them, including Demi Moore, Margaret Qualley, Dennis Quaid.

• Elisabeth — played by Demi Moore
• Sue — played by Margaret Qualley
• Harvey — played by Dennis Quaid
• Fred — played by Edward Hamilton-Clark
• Oliver — played by Gore Abrams
• Troy — played by Oscar Lesage
• Man at Diner — played by Christian Erickson
• Male Nurse — played by Robin Greer
• Doctor — played by Tom Morton
• Diego - Boyfriend — played by Hugo Diego Garcia
• Casting Director — played by Daniel Knight
• Assistant Casting Director — played by Jonathon Carley
• Girl Auditioning / New Year's Eve Show Dancer — played by Jiselle Henderkott
• TV Host — played by Akil Wingate
• Man in Suit #1 - Harvey's Office — played by Vincent Colombe
• Man in Suit #2 — played by Billy Bentley
• Man in Suit #3 — played by Lennard Ridsdale
• Assistant Director - Pump It Up Show — played by Jordan Ford Silver
• 2nd Assistant Director - Pump It Up Show — played by Oscar Salem
• Sue's Assistant — played by Viviane Bossina