American Dad! Season 22 Characters & Cast — No Spoilers
Every character in American Dad! season 22 with photos and the actors who play them, including Seth MacFarlane, Wendy Schaal, Rachael MacFarlane — spoiler-free, nothing from later seasons.
- Stan Smith / Roger (voice) — played by Seth MacFarlane
- Francine Smith (voice) — played by Wendy Schaal
- Hayley Smith (voice) — played by Rachael MacFarlane
- Steve Smith (voice) — played by Scott Grimes
- Klaus (voice) — played by Dee Bradley Baker
- Jeff Fischer (voice) — played by Jeff Fischer
- Dick (voice) — played by David Koechner
- Snot Lonstein (voice) — played by Curtis Armstrong
- Al Tuttle (voice) — played by Richard Kind
- Danuta (voice) / (voice) / Esther Lonstein (voice) — played by Nicole Shabtai
- Avery Bullock (voice) — played by Patrick Stewart
- Jackson (voice) — played by Mike Henry
- (voice) / Izzy (voice) — played by Charlet Chung
- Dr. Weitzman (voice) — played by Matt E. Mixer
- (voice) / Mertz (voice) — played by Judah Miller
- (voice) — played by Josh Robert Thompson
- Billy (voice) / Principal Lewis (voice) — played by Kevin Michael Richardson
- James Garfield (voice) / Dr. Moe Munney (voice) — played by Chris Parnell
- Barry Robinson (voice) — played by Eddie Kaye Thomas
- Memphis Stormfront (voice) — played by Andy Daly
All seasons of American Dad!: full spoiler-free character guide